Story thread · 2 reports / 1 sources
Lsp2 links mTORC1 to TOP mRNA translation and lifespan in Drosophila
nature.com · 1d · first report
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11029-x In Drosophila, the protein Lsp2, which is induced by dietary essential amino acids, is a key physiological effector of mTORC1, and mutant flies that lack the Lsp2 gene exhibit reduced translation of TOP mRNAs and improved longevity.
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